Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers
نویسندگان
چکیده
منابع مشابه
Association of miR-146a, miR-149, miR-196a2, miR-499 gene polymorphisms with ischemic stroke in a Chinese people
This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case-control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was use...
متن کاملRole of polymorphisms in miR-146a, miR-149, miR-196a2 and miR-499 in the development of ovarian cancer in a Chinese population
Here, we carried out an investigation of the relationship between miR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913) and miR-499 (rs3746444) polymorphisms and development of ovarian cancer in a Chinese population. With a hospital-based case-control design, 155 patients and 342 control subjects were involved in the First Affiliated Hospital of Harbin Medical University between Mar...
متن کاملAssociation of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations
BACKGROUND Single nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB). This study aimed to investigate potential associations between the four precursor miRNA SNPs (miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 T > C) and susceptibility to pulmonary TB in the Chines...
متن کاملAssociations of SNPs in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
Colorectal cancer (CRC) is the fourth most common cause of death from cancer and the most common malignancy of the gastrointestinal tract. About 608, 000 deaths are estimated worldwide, accounting for 8% of all cancer deaths (Ferlay et al., 2010). The five-year survival rate of early-stage CRC is 90%, but only 10% if distant metastases are present (Levin et al., 2008). Though the recent statist...
متن کاملAssociation of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.
OBJECTIVE MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. METHODS AND RESULTS Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 pat...
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ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine (CCLM)
سال: 2011
ISSN: 1437-4331,1434-6621
DOI: 10.1515/cclm.2011.708